The association between beta-blocker therapy and daytime sleepiness in obstructive sleep apnoea

Abstract Daytime sleepiness is a cardinal symptom of obstructive sleep apnoea (OSA) and well-recognised side effect beta-blockers, therefore patients with OSA under this treatment may have worse sleepiness. However, the interaction between daytime beta-blockers use has not been thoroughly investigated in before. We analysed data 2183 individuals (1852 331 snorer controls) from 3 countries (Greece, Hungary Moldova). Medical history, including medication usage Epworth Sleepiness Scale (ESS) were recorded. Patients controls divided into somnolent (ESS ≥ 11) non-somnolent < groups, association between-blocker group was multivariate logistic regression analysis adjusted for confounders. Sensitivity analyses performed each cohort, severity subgroups, who did take statins those had polysomnography as diagnostic test. There no relationship beta-blocker ( p = 0.24) or control 0.64) groups. These results similar sensitivity (all > 0.05). ESS related to BMI ρ 0.25), total time 0.07), AHI 0.32), oxygen desaturation index 0.33) minimum saturation – 0.32, all 0.05) OSA, higher hypertension, diabetes cerebro/cardiovascular disease took In general, are associated increased OSA. Thus, diagnosis should discourage initiation treatment, if it clinically indicated.